Aptamers are single-stranded DNA or RNA (ssDNA or ssRNA) molecules that can bind to pre-selected targets including proteins and peptides with high affinity and specificity. These molecules can assume a variety of shapes due to their propensity to form helices and single-stranded loops, explaining their versatility in binding to diverse targets. They are used as sensors, and therapeutic tools, and to regulate cellular processes, as well as to guide drugs to their specific cellular targets. Contrary to the actual genetic material, their specificity and characteristics are not directly determined by their primary sequence, but instead by their tertiary structure.
Scientists at Base Pair Biotechnologies have spent over a decade engineering aptamers. With our multiplexed technology we brought down the costs, now we’re expanding the scope of what affinity reagents can achieve. If your research or development is in the following areas, we’re ready for your call: